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Synthesis 2016; 48(15): 2429-2437
DOI: 10.1055/s-0035-1561428
DOI: 10.1055/s-0035-1561428
paper
The Synthesis of Two Regioisomeric Aldehydes with a Tetrahydrobenzo[b]thiophene Scaffold and Their Application in Solvent-Free Intramolecular 1,3-Dipolar Cycloaddition Reactions
Further Information
Publication History
Received: 12 February 2016
Accepted after revision: 07 March 2016
Publication Date:
26 April 2016 (online)
Abstract
The paper describes the synthesis of two regioisomeric 2-amino-3-formyl- and 3-amino-2-formyl-substituted derivatives of tetrahydrobenzo[b]thiophene and their subsequent thermally initiated reactions with secondary amines to give azomethine ylides that undergo intramolecular 1,3-dipolar cycloadditions. In this way, two series of new fused heterocyclic compounds with three stereogenic centers were prepared. The compounds were identified and their structures were determined.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1561428.
- Supporting Information
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